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NCS Currents June 2016

Fourth Neurocritical Care Research Conference Cements Commitment to Promote International Research Collaborations By Jose Suarez, MD, FNCS Most of our faithful readers already know that The Fourth Neurocritical Care Research Conference: Subarachnoid Hemorrhage took place in Houston, Texas on May 13-15, 2016. We wanted to share with you the good news stemming from this exciting gathering. This year’s conference was successful and exceeded expectations. We had 126 attendees from the U.S., Canada, Germany, The Netherlands, Switzerland, Belgium, Japan, The Philippines, Brazil, Colombia, Ecuador, Hong Kong, and Israel. Ninety percent of attendees completed the program evaluation with the following summary results: 100% satisfaction (90% rated the conference as excellent and 10% as good); 99% thought that the program was fair and balanced; and 99% indicated that there were no perceived conflicts of interest. The faculty roster was very diverse: 35% women, 43% minorities, 33% junior rank or trainees, and 31% from outside the U.S. The overall goal of the Fourth Neurocritical Care Research Conference was to bring together a diverse group of academic scientists, physicians, nurses, pharmacists, and other allied healthcare professionals with a common interest in understanding and advancing research in subarachnoid hemorrhage (SAH) and neurocritical care. The symposium was unique in that it provided a forum to present and discuss the NINDS-supported SAH Common Data Elements (CDE) project (https:// commondataelements.ninds.nih.gov/#page=Default ), latest advances in clinical study design, research tools, and research priorities in the field of SAH. This conference was supported by the CHI Baylor St Luke’s Medical Center ($50,000 – total since 2009: $200,000), the National Institute of Neurological Disorders and Stroke (NINDS) (1R13NS096789-01, P.I. Jose Suarez: $25,000; total since 2009: $74,000), the NCS ($6,500), and the Integra Foundation ($5,000; total since 2009: $30,000), and endorsed by the Baylor College of Medicine. In addition, the following exhibitors contributed to the success of this symposium: Arbor Pharmaceuticals, CHIESI, CSL Behring, Genentech, Medtronic, MOBERG ICU Solutions, NIHON KOHDEN, Ornim, Otsuka, Pfizer, Rythmlink, SAGE, Stryker, and UCB. This two and a half day symposium consisted of the following scientific sessions: 1) Unruptured Cerebral Aneurysms and SAH CDE Project; 2) Special Lectures; 3) Point & Counterpoint: are we doomed to repeat our past mistakes?; 4) Clinical Study Design in SAH; 5) Research Priorities in SAH: a global prospective; and 6) Research Project Presentations and Discussions. In addition, lively, relevant, and interesting discussions were organized at the end of each session. Participants were able to agree on the content of the SAH CDE project and final deadlines for its completion. Furthermore, there was unanimous agreement that international research collaborations were needed to further validate the SAH CDEs and enhance our knowledge of the worldwide impact of this disease. The last day of the meeting included selected outstanding oral presentations by mostly junior faculty and neurocritical care trainees: • Albumin in subarachnoid hemorrhage: The ALISAH II Clinical Trial (Jose Suarez, MD, Baylor College of Medicine, Houston, TX) • Altered consciousness and altered cortical cerebral blood flow in SAH (Sarah Nelson, MD, neurocritical care fellow, Harvard University, Boston, MA) • Enhance epoxyeicosatetraenoic acid (ETTs) metabolism and clinical outcome in SAH (Ross Martini, MD, Oregon Health and Sciences University, Portland, OR) • Effect of cerebellar edema with brainstem compression on auditory evoked responses (Tobias Benjamin Kulik, MD, neurocritical care fellow, Washington University, St Louis, MO) • Monitoring of synaptodendritic injury with advanced diffusion MRI in SAH and TBI (Terrance Kummer, MD, PhD, Washington University, St Louis, MO) At the conclusion of the conference, participants were able to: 1) understand the importance and opportunities for SAH research; 2) discuss recent scientific advances related to the assessment of outcomes and interventions that will have an impact on SAH research; 3) determine the future directions of SAH research; and 4) enhance collaborations via the Neurocritical Care Research Network (NCRN) and other NINDS-funded research networks. The main task ahead will be the design and execution of the International SubarachnoID Hemorrhage Effectiveness Research Registry: The INSIDERR Study. Follow-up organizational meetings will be held in the next few months to brainstorm and organize the study. An international multidisciplinary group of investigators is currently being assembled to develop this project and seek NINDS/NIH funding. Plans are underway for the Fifth Neurocritical Care Research Conference to take place in 2018. We will continue with disease-specific research symposia to focus the objectives, discussions, and conclusions. Stay tuned! Organizing Committee: Jose Suarez, MD (Chair) DaiWai Olson, RN, PhD Paul Vespa, MD R. Loch Macdonald, MD, PhD Eusebia Calvillo, RN R. Loch Macdonald addressing the panel of one of the many discussion and debate sessions held Group picture of attendees at the completion of the presentation of the during the conference Unruptured Cerebral Aneurysms and SAH CDE Project 7


NCS Currents June 2016
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