Trial Name
NCT Number
Title Acronym
Study Design & Characteristics Sponsored Organization
Tenecteplase in Wake-up
Ischemic Stroke Trial
NCT0318136
TWIST
Randomized, placebo-controlled phase 3 trial
Start: June 2017
Est. Study Completion: December 2022
Status: Recruiting
• University Hospital of North Norway
• UiT The Arctic University of Norway
• The Royal Norwegian Ministry of Health
• Norwegian Health Association
Alteplase-Tenecteplase Trial
Evaluation for
Stroke Thrombolysis
NCT0281440
ATTEST-2
Randomized, alteplase-controlled phase 3 trial
Start: October 2016
Est. Study Completion: August 2019
Status: Not yet recruiting
• NHS Greater Glasgow and Clyde
• University of Glasgow
• University of Edinburgh
• Oxford University Hospitals NHS Trust
A Randomized Controlled Trial
of TNK-tPA versus standard of
care for minor ischemic stroke
with proven occlusion
NCT 0239865
TEMP0-2
Randomized, intervention-controlled phase 3 trial
Start: April 2015
Est. Study Completion: March 2021
Status: Recruiting
• University of Calgary
Tenecteplase versus alteplase in
ischemic stroke management
NCT0218020
TALISMAN
Randomized, alteplase-controlled phase 2 and
phase 3 trial
Start: January 2015
Est. Study Completion: June 2020
Status: Withdrawn
• The Ohio State University
Study of tenecteplase versus
alteplase for thrombolysis (clot
dissolving) in acute ischemic
stroke
NCT0194994
NOR-TEST
Randomized, alteplase-controlled phase 3 trial
Start: September 2012
Study Completion: December 31, 2016
Status: Completed
• The Research Council of Norway
• Haukeland University Hospital
Tenecteplase versus alteplase for
Stroke Thrombolysis Evaluation
Trial
ACTRN12613000243718
TASTE
Multicenter, prospective, randomized, openlabel,
blinded, alteplase-controlled
phase 3 trial
Start January 2013
Est. Study Completion: Unknown
Status: Recruiting
• Listed under the Australian New Zealand
Clinical Trials Registry
• John Hunter Hospital Royal Newcastle
Centre
Table 2
30