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NCS Currents Sept 2016

TRANSFORMING THE UNDERSTANDING OF SUPER-REFRACTORY STATUS EPILEPTICUS (SRSE) SRSE is a life-threatening form of status epilepticus that continues or recurs despite multiple therapeutic interventions, including general anesthetics. Rapid treatment and termination of the crisis is crucial, as uncontrolled seizures can take an enormous toll, resulting in neuronal injury, loss of cognitive function, and death.1-5 Copyright 2016 Sage Therapeutics The longer a seizure remains uncontrolled, the poorer the prognosis is for patients1 There are no FDAapproved treatments for SRSE management when status epilepticus continues6 Evidence-based treatment options are needed Sage Therapeutics is committed to discovering and developing life-changing therapies to treat central nervous system disorders, and we are dedicated in our pursuit to deliver new medicines with the goal of making life better for patients and their families. Learn more about SAGE. Visit us at www.sagerx.com References: 1. Bayrlee A, Ganeshalingam N, Kurczewski L, Brophy GM. Treatment of super-refractory status epilepticus. Curr Neurol Neurosci Rep. 2015;15:66. 2. Hocker S, Tatum WO, LaRoche S, Freeman DW. Refractory and super-refractory status epilepticus—an update. Curr Neurol Neurosci Rep. 2014;14:452. 3. Belfort GM, Quirk MC, Hammond RS, et al. Adaptation of a pre-clinical biomarker for SAGE-547 for use in a Phase 1/2 clinical trial for super refractory status epilepticus. Poster presented at: 69th Annual Meeting of the American Epilepsy Society; December 4-8, 2015; Philadelphia, PA. 4. Kanes S, Rosenthal ES, Vaitkevicius H, et al. Results of Phase 1/2 trial of SAGE-547 for super-refractory status epilepticus (547-SSE-201): response and relationship to underlying patient characteristics. Poster presented at: 69th Annual Meeting of the American Epilepsy Society; December 4-8, 2015; Philadelphia, PA. 5. Trinka E, Brigo F, Shorvon S. Recent advances in status epilepticus. Curr Opin Neurol. 2016;29:189-198. 6. Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain. 2011;134:2802-2818.


NCS Currents Sept 2016
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